Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, January 14

Lecture 1: Introduction
Lecturer: David Dickman

N/A

9:00 - 10:30

Wed., January 16

Lecture 2: Development of the Nervous System
Lecturer: Joel Price

Heimer: Chapter 2
OR KSJ: Chapters 17, 52
OR Haines: Chapters 1, 5
OR Purves: Chapters 1, 22

1:00 - 4:00

Wed., January 16

Lab 1: Human Gross Anatomy & Blood Supply; Human Brain Overview, Dissection I
Lecturers: Joel Price, Woolsey, Galvin

Woolsey: Part I & II

9:00 - 10:30

Friday, January 18

Lecture 3: Measurement of Behavior
Lecturer: Steve Petersen

N/A

Time

Date

Title + Lecturer

Readings

N/A

Monday, January 21

MLK Holiday--no class

N/A

9:00 - 10:30

Wed., January 23

Lecture 4: Synaptic Organization of the Brain
Lecturer: Andreas Burkhalter

KSJ: Pp. 67-87, 98, 175-186, 207-228, 418-419, 426-428, 462-463, 516-518, 533-536
OR Haines: Chapters 4
OR Purves: Chapters 5, 6

1:00 - 4:00

Wed., January 23

Lab 2: Mouse Comparative Gross Anatomy
Lecturers: Price, Burkhalter, Dickman

N/A

9:00 - 10:30

Friday, January 25

Lecture 5: Receptors/Neural Coding/Psychophysics
Lecturer: David Dickman

KSJ: Chapter 21

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, January 28

Lecture 6: Maps, Columns, Hierarchy
Lecturer: Steve Petersen

Felleman DJ, Van Essen DC. Distributed hierarchical processing in the primate cerebral cortex. Cereb Cortex, 1991, 1: 1-47.

9:00 - 10:30

Wed., January 30

Lecture 7: Visual Sensory Processing
Lecturer: David Van Essen

KSJ: Chapters 26, 27, 30
OR Haines: Chapter 20
OR Purves: Chapters 11, 12

1:00 - 4:00

Wed., January 30

Lab 3: Demos - Structure and Function of Synapses
Lecturers: Mennerick, Holy, Price, Burkhalter

N/A

9:00 - 10:30

Friday, February 1

Lecture 8: Sensory Plasticity
Lecturer: Andreas Burkhalter

KSJ: Pp. 1019-1021, 1115-1130

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, February 4

Discussion 1: Top-down Processing
Lecturer: Andreas Burkhalter

Hupe JH. Cortical feedback improves discrimination between figure and backgrounds by V1, V2, and V3 neurons. Nature, 1998, 394: 784-787.

Stettler, DD. Lateral connectivity and contextural interactions in macaque primary visual cortex. Neuron, 2002, 36: 739-750.

9:00 - 10:30

Wed., February 6

Lecture 9: Visual Recognition
Lecturer: David Van Essen

KSJ: Chapter 28

1:00 - 4:00

Wed., February 6

Lab 4: Eye & Visual System Anatomy and Visual Perception Demos
Lecturers: Burkhalter, Price

N/A

9:00 - 10:30

Friday, February 8

Discussion 2: Sensory Plasticity
Lecturer: Andreas Burkhalter

Trachtenberg JT, Trepel C, and Stryker MP. Rapid extracellular plasticity in the absence of thalamocortical plasticity in the developing primary visual cortex. Science, 2000, 287: 2092-2032.

Trachtenberg JT and Stryker MP. Rapid anatomical plasticity of horizontal connections in the developing visual cortex. J. Neuroscience, 2002, 21: 3476-3482.

Time

Date

Title + Lecturer

Readings

8:45 - 9:30

Monday, February 11

Lecture 10: Linking Neurons to Behavior - Motion Processing I
Lecturer: Dora Angelaki

Britten HK et al., The analysis of visual motion: a comparison of neuronal and psychophysical performance. J Neuroscience. 1992, 12: 4745-4765.

Britten KH et al. A relationship between behavioral choice and the visual responses of neurons in macaque MT. Vis. Neurosci., 1996, 13: 87-100.

9:00 - 10:30

Wed., February 13

Lecture 11: Linking Neurons to Behavior - Motion Processing II
Lecturer: Dora Angelaki

Gu Y et al. A functional link between area MSTd and heading perception based on vestibular signals. Nature Neurosci., 2007, 10: 1038-1047.

Plus attached Review by Knill & Pouget, 2004

1:00 - 4:00

Wed., February 13

Lab 5: Demo - Monkey Neurophysiology & Behavior
Lecturers: Dora Angelaki (2nd floor, E McDonnell)
Larry Snyder (3rd floor E McDonnell)

N/A

9:00 - 10:30

Friday, February 15

Discussion 3: Population Coding Mechanisms
Lecturer: Dora Angelaki
Larry Snyder

Nichols MJ and Newsome WT. Middle temporal visual area microstimulation influences veridical judgments of motion direction. J Neurosci. 2002, 22: 9530-9540.

Salsman and Newsome. Neuron mechanisms for forming a perceptual decision. Science, 1994, 264: 231-237.

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, February 18

Lecture 12: Pain
Lecturer: Rob Gereau

KSJ: Chapter 22, 24
OR Haines: Chapter 18
OR Purves: Chapter 10

9:00 - 10:30

Wed., February 20

Lecture 13: Somatic Sensation
Lecturer: Thomas Woolsey

KSJ: Chapters 22, 23
OR Haines: Chapter 17
OR Purves: Chapter 9

1:00 - 4:00

Wed., February 20

Lab 6: Somatic Sensory System
Lecturers: Thomas Woolsey
Joel Price
James Galvin

Supplemental/Classical DRG Paper

9:00 - 10:30

Friday, February 22

Lecture 14: Chemical Senses
Lecturer: David Dickman

KSJ: Chapters 32
OR Haines: Chapter 23
OR Purves: Chapter 15

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, February 25

Lecture 15: Auditory System
Lecturer: Mark Warchol

KSJ: Chapters 30, 31
OR Haines: Chapter 21
OR Purves: Chapter 13

9:00 - 10:30

Wed., February 27

Lecture 16: Vestibular System
Lecturer: David Dickman

Haines: Dickman JD, The Vestibular System

1:00 - 4:00

Wed., February 27

Lab 7: Auditory/Vestibular System
Lecturers: Dennis Barbour
David Dickman
Joel Price

N/A

9:00 - 10:30

Friday, February 29

Discussion 4: The Barn Owl Auditory System
Lecturer: Dennis Barbour
David Dickman
Mark Warchol

Knudsen EI. Instructed learning in the auditory localization pathway of the barn owl. Nature, 2002, 417: 322-328.

McAlpin D. Creating a sense of auditory space. J Physiol., 2005, 566: 21-28.

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, March 3

Review Session for Midterm Exam
Lecturers: Dora Angelaki
Andreas Burkhalter
Mark Warchol
Joel Price
Steve Petersen

N/A

10:30 - 11:00

Monday, March 3

Delivery of Midterm Exam
[2007 Midterm Exam (No Answer Key)]
[2008 Midterm Exam]

N/A

1:00 - 2:00

Wed., March 5

Lab Practical Exam
[2005 Lab Practical Exam w/ answers]

[2006 Lab Practical Exam]
[2006 Lab Practical Exam Answer Key]

[2007 Lab Practical Exam]
[2007 Lab Practical Exam Answer Key]

[Saturday Practical Review Session]
[Saturday Practical Review Session Answer Key]

[2008 Practical Exam I]
[2008 Practical Exam I Answer Key]

N/A

5:00

Friday, March 7

Deadline to turn in Midterm Exam

N/A

Time

Date

Title + Lecturer

Readings

N/A

Monday, March 10

SPRING BREAK

N/A

N/A

Wed., March 12

SPRING BREAK

N/A

N/A

Friday, March 14

SPRING BREAK

N/A

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, March 17

Lecture 17: Biological Oscillators - Central Pattern Generators
Lecturer: Paul Stein

KSJ: Chapter 37

9:00 - 10:30

Wed., March 19

Lecture 18: Biological Oscillators: Circadian Systems
Lecturer: Erik Herzog

Zigmond: Chapter 45, pp. 1189-1206.

1:00 - 4:00

Wed., March 19

Lab 8: Demos - Biological Oscillators (click for info.)
Lecturers: Paul Stein
Erik Herzog
Location: Monsanto Labs 205, Danforth Campus

N/A

9:00 - 10:30

Friday, March 21

Lecture 19: Sleep
Lecturer: Paul Shaw

KSJ: Chapter 47
OR Purves: Chapter 28

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, March 24

Lecture 20: Oculomotor System
Lecturer: Larry Snyder

KSJ: Chapter 39
OR Haines: Chapter 28
OR Purves: Chapter 20

Optional: Robinson D. Eye movement control in primates. Science, 1968, 161: 1219-1224.

9:00 - 10:30

Wed., March 26

Lecture 21: Neural Representations of Space
Lecturer: Larry Snyder

Zigmond: Chapter 53, pp. 1363-1383.
Sparks D. Sensorimotor integration in the primate superior colliculus; seminars in the neurosciences. 1991, 3: 39-50.

Jay and Sparks D. Auditory receptive fields in primate superior colliculus shift with changes in eye position. Nature, 1984, 309: 345-347.

1:00 - 4:00

Wed., March 26

Lab 9: Oculomotor System
Lecturers: Dan Moran
Larry Snyder
Location: Whitaker Hall, Danforth Campus

N/A

9:00 - 10:30

Friday, March 28

Discussion 5: Reference Frames
Lecturer: Dora Angelaki
Larry Snyder

For Background: Avilac M et al. Reference frames for representing visual and tactile locations in parietal cortex. Nature Neuroscience, 2005, 8: 941-949.

For Discussion: Deneve S et al. Efficient computation and cue integration with noisy population codes. Nature Neuroscience, 2001, 4: 826-831.

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, March 31

Lecture 22: Motor System - System Reflexes
Lecturer: Tom Thach

KSJ: Chapters 34, 36
OR Haines: Chapter 24
OR Purves: Chapter 16

9:00 - 10:30

Wed., April 2

Lecture 23: Motor Cortex
Lecturer: Tom Thach

KSJ: Chapter 38
OR Haines: Chapter 25
OR Purves: Chapter 17

1:00 - 4:00

Wed., April 2

Lab 10: Motor System Anatomy - Motor Reflex Lab
Lecturers: Joel Price
James Galvin
Tom Thach

N/A

9:00 - 10:30

Friday, April 4

Lecture 24: Basal Ganglia & Cerebellum
Lecturer: Tom Thach

KSJ: Chapters 38, 42
OR Haines: Chapters 25, 27
OR Purves: Chapters 18, 19

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, April 7

Lecture 25: Motor Cortex Control & Prosthesis
Lecturer: Dan Moran

KSJ: Chapter 38
OR Haines: Chapter 25
OR Purves: Chapter 17

9:00 - 10:30

Wed., April 9

Discussion 6: Recovery of Function, Spinal & Motor Cortex Injury
Lecturer: Tom Thach

For Background: Sanes JN et al. Plasticity and primary motor cortex. Ann. Rev. Neuroscience, 2000, 23: 393-415.

For Discussion: De Leon RD et al. Retention of hindlimb stepping ability in adult spinal cats after the cessation of step training. J. Neurophysiol., 1999, 81: 85-94.
Kleim JA et al. Functional reogranization of the rat motor cortex following motor skill learning. J. Neurophysiol., 1998, 80: 3321-3325.

1:00 - 4:00

Wed., April 9

Lab 11: Cerebellum & Basal Ganglia
Lecturers: Joel Price
Tom Thach

N/A

9:00 - 10:30

Friday, April 11

Lecture 26: Autonomic Nervous System
Lecturer: Joel Price

KSJ: Chapter 49
OR Haines: Chapter 29
OR Purves: Chapter 21

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, April 14

Lecture 27: Central Control of Visceral Function
Lecturer: Joel Price

See April 11 Readings

9:00 - 10:30

Wed., April 16

Lecture 28: Emotion
Lecturer: Joel Price

KSJ: Chapter 50
ORPurves: Chapter 29

1:00 - 4:00

Wed., April 16

Lab 12: Demo - Imaging
Lecturer: Steve Petersen
Location: East Building Imaging Facility

N/A

9:00 - 10:30

Friday, April 18

Discussion 8: Reward Systems and the Basal Ganglia
Lecturer: Joel Price

For Background: Schultz W et al. Changes in behavior-related neuronal activity in the striatum during learning. Trends Neuroscience, 2003, 26: 321-328.

For Discussion Padoa-Schioppa C et al. Neurons in the orbitofrontal cortex encode economic value. Nature, 2006, 441: 223-226.

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, April 21

Lecture 29: Learning & Memory I
Lecturer: Joel Price

KSJ: Chapter 62
OR Purves: Chapter 31

9:00 - 10:30

Wed., April 23

Lecture 30: Learning & Memory II
Lecturer: Steve Petersen

Wagner AD et al. Building memories: remembering and forgetting of verbal experiences as predicted by brain activity. Science, 1998, 281: 1188-1191.

1:00 - 4:00

Wed., April 23

Lab 13: Brain Dissection II/Limbic System Anatomy
Lecturer: Joel Price
James Galvin

N/A

9:00 - 10:30

Friday, April 25

Lecture 31: Attention
Lecturer: Steve Petersen

Posner et al. Attention and cognitive control. In: Solo RL (ed.) Information processing and cognition. LEA, Hillsdale, N.J., 1975, pp. 55-85.

Neely JH. Semantic priming and retrieval from lexical memory: roles of inhibition less spreading activation and limited-capacity attention. J. Exp. Psychol., 1977, 106: 226-254.

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, April 28

Discussion 9: Neuronal Correlates of Attention
Lecturers: Larry Snyder
Steve Petersen

For Discussion: Reynolds JH et al. Competitive mechanisms subserve attention in macaque areas V2 and V4. J. Neuroscience, 1999, 19: 1736-1753.

9:00 - 10:30

Wed., April 30

Lecture 32: Language
Lecturer: Steve Petersen

Petersen SE et al. Positron emission tomographic studies of the processing of single words. J. Cogn. Neurosci., 1989, 1: 153-170.

9:00 - 10:30

Friday, May 2

Review Session for Final Exam
Lecturers: Tom Thach
Larry Snyder
Paul Stein
Erik Herzog
Steve Petersen
Joel Price

N/A

10:30 - 11:00

Monday, March 3

Delivery of Final Exam
[2008 Final Exam]

N/A

Time

Date

Title + Lecturer

Readings

9:00 - 10:30

Monday, May 5

Lab Practical Exam
[2006 Lab Practical Exam]
[2006 Lab Practical Exam Answer Key]

[2007 Final Lab Practical Exam]
[2007 Final Lab Practical Exam Answer Key]

N/A

5:00

Wed., May 7

Deadline for Final Exam to be turned in

N/A